These first form dimers, and subsequently orientate in a head-to-tail fashion to produce filaments. The fibrillar nature of the lamina arises from the building blocks of the lamina the laminin proteins. It is highly proteinaceous and is fibrillar in appearance. The Nuclear Lamina is a structure that is located near the inner nuclear membrane. These subcompartments together form the nucleoskeleton, and include the following:Ĭell and Nucleus, Image Copyright: sanjayart / Shutterstock Nuclear Membrane (nuclear envelope) These facilitate the various nuclear processes, particularly gene expression. The mechanical support and functional organization of the nucleus is contributed by several nuclear subcompartments, or nuclear bodies. Additionally, the nucleus dynamically interacts with the surrounding cytoskeleton. The nucleus is mechanically stable, possessing the ability to resist deformation. The nucleus contains approximately 2m of DNA which is enmeshed by the nuclear envelope, a crosslinked network of proteins and membranes. The effect of these processes extends to affecting cellular metabolism and growth. These processes include transcription, replication, splicing and ribosome biogenesis. The cell nucleus is the site of many important biological functions of the eukaryotic cell. In this review, an analysis is performed on the main intracellular signaling pathways that take part in the cellular proliferation process, and the potential use of some components of these pathways as target for therapeutic interventionism are also underlined.By Deborah Fields, B.Sc. Some of them participate simultaneously or in a nearly-consecutive progression to generate a cellular phenotypic change. They participate in cell homeostasis processes for structural and functional maintenance. More than 300 intracellular signaling pathways have been identified in human cells. The identification of these intracellular signaling pathways in different cellular types has required a long journey of experimental work. These molecules are ordered in clusters of receptor molecules of extracellular signals, transducers, sensors and biological response effectors. Different proteins are organised in the form of functional clusters, pathways or networks. Proteins are the major components of the cells. Nowadays, cellular physiology is best understood by analysing their interacting molecular components. Varias de ellas participan de forma simultánea o cercanamente consecutiva en la generación de un cambio fenotípico celular.Įn esta revisión analizamos las principales vías de señalización intracelular que participan en el proceso de proliferación celular y remarcamos la estrategia de utilizar algunos componentes de estas vías como blanco de un potencial intervencionismo terapéutico. Se han identificado más de 300 vías de señalización intracelular en las células humanas, las cuales participan en los procesos celulares básicos y especializados para mantener la homeostasis estructural y funcional. La identificación de las diferentes vías de señalización intracelulares en los diferentes tipos de células ha requerido largas jornadas de trabajo experimental. Estos conjuntos se encuentran organizados en moléculas receptoras de señales extracelulares, transductoras, sensoras y efectoras de respuestas biológicas. Las diferentes proteínas se organizan en asociaciones formando conjuntos, vías, o redes funcionales. Las proteínas son las principales biomoléculas que constituyen las células. La fisiología celular es actualmente mejor entendida a partir de sus componentes moleculares interactuantes.
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